Toni Wilkinson
Toni Wilkinson
Ph.D. Student
University of California, Irvine
Speech Title: 
Transcutaneous multi-biomarker sensing on a single flexible fiber
Abstract: 
The laboratory of Elliot Botvinick at the University of California, Irvine is developing a technology for the measurement of multiple physiological biomarkers by a single hair-thin transcutaneous flexible fiber that houses a linear array of optrodes. This technology relies on chemistry and photonics for specificity and sensitivity across pathophysiological ranges of biomarker concentration. The presentation will discuss the foundational technology of each optrode, medical applications, and current thrusts to add new target biomarkers. Examples include the ketone beta-hydroxybutyrate and insulin for diabetes management, as wells as pH, which in combination with our current lactate monitoring optrode can stratify conditions such as metabolic and respiratory acidosis. To date, optrodes for oxygen, glucose, and lactate are developed on a single probe with clinical studies of exercise in type 1 diabetes underway. Future plans are to develop a multitude of probe embodiments, each targeting a medical condition.
Bio: 

Toni Wilkinson is a PhD student in Professor Elliot Botvinick’s laboratory. She is a nontraditional student that pursued her biomedical engineering interests after a long and fruitful career as a successful entrepreneur and business owner. Motivated by a desire to improve health care technologies using light, she specifically decided to go back to school to train at the Beckman Laser Institute and biomedical engineering department in order to innovate in the medical device space. Her current efforts include serving as innovator and project lead in the advancing of the laboratory’s wearable detection system by adding ketone and insulin monitoring to prevent the onset of diabetic ketoacidosis in type 1 diabetics, followed by clinical study of these technologies in collaboration with the University of Melbourne, Australia.

The Henry Samueli School of Engineering

Tel Aviv University